Using information gleaned from your readings on Eicosanoids, give a clear biochemical response
to these questions (Your answers should not be more than 2 pages):
a. A 65 year old retired construction worker is referred to the dialysis clinic following a
recent diagnosis of chronic kidney disease due to a prolonged use of of the NSAID
Ibuprofen. Explain the biochemical basis of NSAID nephropathy?
b. What is the biochemical rationale for the use of low dose aspirin in patients with
coronary artery disease? Why is Ibuprofen not a good substitute for aspirin in this
case?
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